RNA Polymerase Clamps Down
نویسندگان
چکیده
منابع مشابه
RNA Polymerase Clamps Down
RPB1 (which is not present in bacterial RNAP) is not Gene expression in all cells requires synthesis of mRNAs resolved in the structures. by an evolutionarily conserved, multisubunit RNA polyAs RNAP transcribes (Figure 1B), DNA enters the enmerase (RNAP). A series of recent breakthroughs in zyme in the first chamber, termed the jaw-lobe module. X-ray crystallography of RNAP has begun to reveal ...
متن کاملZinc'ing down RNA polymerase I
The three major eukaryotic RNA polymerases contain zinc. The presence of zinc cations bound to various polymerase subunits was determined by early work describing the purification of eukaryotic RNA polymerases, including RNA polymerase I (RNAP I), the enzyme that produces three of the four rRNAs. These pioneer studies also showed that zinc is required for the activity of various eukaryotic RNA ...
متن کاملEurope clamps down on antibiotic misuse.
terious effects of antimicrobial resistance (AMR), the European Commission is calling on all European Union countries to prohibit antibiotic use in animals and humans without veterinary or medical prescription. The requirement is among a number of measures urged in a 12-point, fiveyear Action plan against the rising threats from Antimicrobial Resistance aimed at requiring more prudent use of an...
متن کاملEnhancement of RNA Interference Effect in P19 EC Cells by an RNA-dependent RNA Polymerase
Background: RNA interference (RNAi) is a phenomenon uses double-stranded RNA (dsRNA) to specifically inhibit gene expression. The non-specific silencing caused by interferon response to dsRNA in mammalian cells limits the potential of utilizing RNAi to study gene function. Duplexes of 21-nucleotide short interfering dsRNA (siRNA) inhibit gene expression by RNAi. In some organisms, siRNA can als...
متن کاملTie Me Up, Tie Me Down: Inhibiting RNA Polymerase
Mechanistic understanding of antibiotic action can yield crucial insights that aid in the design of new antibiotics. In this issue, Mukhopadhyay et al. (2008) uncover the mechanism by which the antibiotic myxopyronin inhibits bacterial RNA polymerase, suggesting a new target region in RNA polymerase for inhibitor design.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2001
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(01)00381-6